{"id":543,"date":"2021-10-29T14:58:56","date_gmt":"2021-10-29T11:58:56","guid":{"rendered":"https:\/\/www.silmasaatio.fi\/uraauurtavaa-silmatutkimusta\/"},"modified":"2024-11-22T11:34:49","modified_gmt":"2024-11-22T09:34:49","slug":"banbrytande-ogonforskning","status":"publish","type":"post","link":"https:\/\/www.silmasaatio.fi\/sv\/banbrytande-ogonforskning\/","title":{"rendered":"Banbrytande \u00f6gonforskning"},"content":{"rendered":"

\"\"<\/p>\n

Den internationella forskargruppen Helsinki Retina Research Group vid Helsingfors universitet f\u00f6rs\u00f6ker hitta nya, innovativa behandlingsmetoder f\u00f6r att fr\u00e4mja behandlingen av \u00f6gonsjukdomar.<\/em><\/p>\n

Jag b\u00f6rjade som medicinstuderande p\u00e5\u00a0Haartman-Institutet<\/a>\u00a0vid Helsingfors universitet, i forskningsgruppen hos hj\u00e4rt- och organtransplantationskirurgen professor Karl Lemstr\u00f6m. V\u00e5ra observationer av experimentella organtransplantationer, virusf\u00f6rmedlad genterapi, tillv\u00e4xtfaktorer f\u00f6r blod- och lymfk\u00e4rl, organtransplantationsimmunologi och reglering av mikroblodcirkulation till\u00e4mpades i organtransplantationer och f\u00f6rs\u00f6ksuppst\u00e4llningen i randomiserade studier.<\/p>\n

Intressanta kontaktpunkter finns mellan \u00f6gonforskningen och banbrytande observationer av en cancerforskare vid\u00a0Harvarduniversitetet<\/a>\u00a0\u00a0Judah Folkman<\/a>. De f\u00f6rklarar hur v\u00e4vnaders tillv\u00e4xt och olika slags sjukdomar s\u00e5som leder till nybildning av k\u00e4rl och varf\u00f6r broskytor och hornhinnan inte f\u00e5r n\u00e5gra blodk\u00e4rl.<\/p>\n

P\u00e5 motsvarande s\u00e4tt f\u00e5r hornhinnan hos en d\u00e4ggdjursart helt fram till vuxen\u00e5ldern, och den ifr\u00e5gavarande arten konstaterades ocks\u00e5 sakna produktion av l\u00f6slig receptor p\u00e5 hornhinnan, som skulle f\u00f6rhindra blodk\u00e4rlstillv\u00e4xtfaktorns funktion.<\/p>\n

Ett minnesv\u00e4rt \u00f6gonblick i min karri\u00e4r var n\u00e4r chefen f\u00f6r hj\u00e4rtcentrum vid Harvard\u00a0Joren Madsen<\/a>\u00a0n\u00e4mnde hur de med \u00e5beropande av v\u00e5ra resultat appellerade till senaten f\u00f6r \u00e4ndring av lagstiftningen och definitionen av hj\u00e4rnd\u00f6d.<\/p>\n

Avancerad riktad medicinering f\u00f6r \u00f6gonsjukdomar<\/h2>\n

Molekyler som bromsar tillv\u00e4xten av blodk\u00e4rl hittades f\u00f6rst bland annat genom extraktion fr\u00e5n hornhinna.\u00a0 Riktade mediciner som utvecklats f\u00f6r\u00a0\u00e5ldersbetingad v\u00e5t makuladegeneration<\/a>\u00a0st\u00e4rkte misstanken att tillv\u00e4xten av nya blodk\u00e4rl kunde bromsas med l\u00f6sliga \u00e4mnen som inaktiverade tillv\u00e4xtfaktorn f\u00f6r blodk\u00e4rl.<\/p>\n

Det \u00e4r fascinerande att regleringen av blodk\u00e4rl, deras t\u00e4ta kopplingar och sp\u00e4nningsstatus f\u00f6r de omgivande st\u00f6dcellerna som liknar glatt muskel samt olika slags tillv\u00e4xtfaktorer och signalsubstanser p\u00e5verkar b\u00e5de \u00e5terh\u00e4mtningen efter starroperationer, avst\u00f6tningsreaktionen efter hornhinnetransplantation, inflammation i regnb\u00e5gshinna, glaukom, diabetesretinopati och uppkomsten av och medicineringen mot m\u00e5nga andra \u00f6gonsjukdomar.<\/p>\n

Topp\u00f6gonblick under min forskningskarri\u00e4r<\/h2>\n

De b\u00e4sta \u00f6gonblicken under min forskningskarri\u00e4r har varit n\u00e4r arbetet g\u00e5tt fram\u00e5t och de som jag handlett med deras avhandlingar har lyckats.\u00a0\u00a0Helsinki Retina Research Group<\/a>\u00a0grundades 2015. Till v\u00e5r grupp har erfarna post doc-forskare fr\u00e5n Polen och Israel anslutit sig och vi har under de senaste 5 \u00e5ren publicerat fler \u00e5n 60 artiklar i ansedda publikationer inom \u00f6gonsjukdomsomr\u00e5det. Observationerna fr\u00e5n de register- och behandlingsstudier som vi inlett med det internationella samarbetet som grund hj\u00e4lper till att rikta fr\u00e5gest\u00e4llningarna kring utmaningar inom behandlingen av \u00f6gonsjukdomar r\u00e4tt.<\/p>\n

Silm\u00e4s\u00e4\u00e4ti\u00f6s st\u00f6d<\/a>\u00a0\u00e4r viktigt f\u00f6r att g\u00f6ra mitt forskningsarbete m\u00f6jligt. Det finns fortfarande m\u00e5nga steg att ta f\u00f6r att forts\u00e4tta utveckla behandlingen av \u00f6gonsjukdomar.\u00a0 Som finl\u00e4ndska forskare kan vi stolt delta i utvecklingen av behandlingar.<\/p>\n

\"\"<\/p>\n

Artikelf\u00f6rfattaren \u00e4r Med dr, docent, specialistl\u00e4kare inom \u00f6gonsjukdomar, FEBO, EMBA\u00a0Raimo M. Tuuminen<\/strong>. Han arbetar som specialistl\u00e4kare inom \u00f6gonsjukdomar vid Kymmenedalens centralsjukhus varifr\u00e5n han \u00e4r tj\u00e4nstledig f\u00f6r n\u00e4rvarande.\u00a0\u00a0I Helsingfors universitets Helsinki Retina Research Group fungerar docent Tuuminen som ledare f\u00f6r forskningsgruppen<\/p>\n","protected":false},"excerpt":{"rendered":"

Den internationella forskargruppen Helsinki Retina Research Group vid Helsingfors universitet f\u00f6rs\u00f6ker hitta nya, innovativa behandlingsmetoder f\u00f6r att fr\u00e4mja behandlingen av \u00f6gonsjukdomar. Jag b\u00f6rjade som medicinstuderande…<\/p>\n","protected":false},"author":1,"featured_media":358,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-543","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-aktuell"],"yoast_head":"\nBanbrytande \u00f6gonforskning - Silm\u00e4s\u00e4\u00e4ti\u00f6<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.silmasaatio.fi\/sv\/banbrytande-ogonforskning\/\" \/>\n<meta property=\"og:locale\" content=\"sv_SE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Banbrytande \u00f6gonforskning - Silm\u00e4s\u00e4\u00e4ti\u00f6\" \/>\n<meta property=\"og:description\" content=\"Den internationella forskargruppen Helsinki Retina Research Group vid Helsingfors universitet f\u00f6rs\u00f6ker hitta nya, innovativa behandlingsmetoder f\u00f6r att fr\u00e4mja behandlingen av \u00f6gonsjukdomar. 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